SP-H004 Pure Natural Milk Thistle Extract with Silymarin Silibinin for Liver Protection

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Product Detail

Product Tags

Milk Thistle Extract-Silymarin

Latin name: Silybum marianum L

Chinese name: Shui Fei Si Su

Family: Composite

Partused: Whole


Silymarin 80%UV,70%UV;80%HPLC;

Silybin  99%,95%,90%,85% HPLC


Silymarin, a plant flavonoid from milk thistle (Silybum marianum)  was first evaluated for its protective effect against UV irradiation-induced apoptosis in human malignant melanoma cells. Treatment with silymarin significantly inhibited UV irradiation-induced apoptosis. Activities of caspase-9 and caspase-3 in UV-irradiated cells were effectively reduced by silymarin in a dose-dependent manner. It is suggested that the inhibitory effect of silymarin is exerted by blockage of the caspase/ICAD pathway after increased expression of Bcl-x(L) protein and activation of the ERK/MAPK pathway.


Silymarin is a powerful antioxidant said to protect liver cells (and other cells in the body and brain) from toxins. Sylimarin apparently promotes liver cell protein synthesis and decreases the oxidation of glutathione. Milk thistle or silymarin may potentially be beneficial in a number of diseases involving the liver, if in the early stages. Silymarin is not likely to work in cases of late stage cirrhosis. Early research indicates that silymarin may also have anti-cancer properties.

Several studies have demonstrated that diabetic patients with cirrhosis require insulin treatment because of insulin resistance. As chronic alcoholic liver damage is partly due to the lipoperoxidation of hepatic cell membranes, anti-oxidizing agents may be useful in treating or preventing damage due to free radicals. The aim of this study was to ascertain whether long-term treatment with silymarin is effective in reducing lipoperoxidation and insulin resistance in diabetic patients with cirrhosis. METHODS: A 12-month open, controlled study was conducted in two well-matched groups of insulin-treated diabetics with alcoholic cirrhosis. One group (n=30) received 600 mg silymarin per day plus standard therapy, while the control group (n=30) received standard therapy alone. The efficacy parameters, measured regularly during the study, included fasting blood glucose levels, mean daily blood glucose levels, daily glucosuria levels, glycosylated hemoglobin (HbA1c) and malondialdehyde levels. RESULTS: There was a significant decrease in fasting blood glucose levels, mean daily blood glucose levels, daily glucosuria and HbA1c levels already after 4 months of treatment in the silymarin group. In addition, there was a significant decrease in fasting insulin levels and mean exogenous insulin requirements in the treated group, while the untreated group showed a significant increase in fasting insulin levels and a stabilized insulin need. These findings are consistent with the significant decrease in basal and glucagon-stimulated C-peptide levels in the treated group and the significant increase in both parameters in the control group. Another interesting finding was the significant decrease in malondialdehyde/levels observed in the treated group. CONCLUSIONS: These results show that treatment with silymarin may reduce the lipoperoxidation of cell membranes and insulin resistance, significantly decreasing endogenous insulin overproduction and the need for exogenous insulin administration.

The dose of silymarin used in studies has ranged from 200 to 800 mg per day.

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